Cic edizioni internazionali
Clinical Cases in mineral and bone metabolism

Evaluation of bone microstructure in CRPS-affected upper limbs by HR-pQCT

Original Article, 54 - 59
doi: 10.11138/ccmbm/2017.14.1.054
Tag this article
Abstract
Enhanced HTML Full text PDF
Introduction. Complex regional pain syndrome (CRPS) is a major complication after trauma, surgery, and/or immobilization of an extremity. The disease often starts with clinical signs of local inflammation and develops into a prolonged phase that is characterized by trophic changes and local osteoporosis and sometimes results in functional impairment of the affected limb. While the pathophysiology of CRPS remains poorly understood, increased local bone resorption plays an undisputed pivotal role. The aim of this retrospective clinical study was to assess the bone microstructure in patients with CRPS.
Methods. Patients with CRPS type I of the upper limb whose affected and unaffected distal radii were analyzed by high-resolution peripheral quantitative computed tomography (HR-pQCT) were identified retrospectively.
The osteology laboratory data and dual-energy X-ray absorptiometry (DXA) images of the left femoral neck and lumbar spine, which were obtained on the same day as HR-pQCT, were extracted from the medical records.
Results. Five patients were identified. The CRPS-affected upper limbs had significantly lower trabecular numbers and higher trabecular thicknesses than the unaffected upper limbs. However, the trabecular bone volume to total bone volume and cortical thickness values of the affected and unaffected sides were similar. Trabecular thickness tended to increase with time since disease diagnosis.
Discussion. CRPS associated with significant alterations in the bone microstructure of the affected upper limb that may amplify as the duration of disease increases.

Vol. XIV (No. 1) 2017 January - April

  1. From the Editor-in-Chief
    Brandi M.L.
    doi: 10.11138/ccmbm/2017.14.1.011
  2. Low-dose diclofenac in patients with fragility fractures
    Vannucci L., Fossi C., Gronchi G., Brandi M.L.
    doi: 10.11138/ccmbm/2017.14.1.015
  3. Vitamin D levels and their impact on mineral metabolism in HIV infected patients: an exploratory study
    Mastaglia S., Watson D., Bello N., Fridman V., Stecher D., Oliveri B.
    doi: 10.11138/ccmbm/2017.14.1.018
  4. New quantitative ultrasound techniques for bone analysis at the distal radius in hip fracture cases: differences between femoral neck and trochanteric fractures
    Horii M., Fujiwara H., Sakai R., Sawada K., Mikami Y, Toyama S., Ozaki E., Kuriyama N., Kurokawa M., Kubo T.
    doi: 10.11138/ccmbm/2017.14.1.023
  5. Use of teriparatide off-label: our experience and review of literature
    Ciurlia E., Tranquilli Leali P., Doria C.
    doi: 10.11138/ccmbm/2017.14.1.028
  6. The effects of zoledronic acid on ECG: a prospective study on patients with bone metastatic cancer
    Demirtas D., Bilir C., Demirtas A.O., Engin H.
    doi: 10.11138/ccmbm/2017.14.1.035
  7. A comparison of two fixation methods for femoral trochanteric fractures: a new generation intramedullary system vs sliding hip screw
    Carulli C., Piacentini F., Paoli T., Civinini R., Innocenti M.
    doi: 10.11138/ccmbm/2017.14.1.041
  8. The use of cholecalciferol in patients with hip fracture
    Cianferotti L., Parri S., Gronchi G., Civinini R., Brandi M.L.
    doi: 10.11138/ccmbm/2017.14.1.048
  9. Evaluation of bone microstructure in CRPS-affected upper limbs by HR-pQCT
    Mussawy H., Schmidt T., Rolvien T., Rüther W., Amling M.
    doi: 10.11138/ccmbm/2017.14.1.054
  10. Molecular genetics in primary hyperparathyroidism: the role of genetic tests in differential diagnosis, disease prevention strategy, and therapeutic planning. A 2017 update
    Marini F., Cianferotti L., Giusti F., Brandi M.L.
    doi: 10.11138/ccmbm/2017.14.1.060
  11. Bone health in menopausal women: a role for General Practitioners
    Michieli R., Musto M.
    doi: 10.11138/ccmbm/2017.14.1.071
  12. Legg-Calvé-Perthes disease: classifications and prognostic factors
    Rampal V., Clément J.-L., Solla F.
    doi: 10.11138/ccmbm/2017.14.1.074
  13. Transient osteoporosis of the hip with a contralateral delayed involvement: a case report
    Iannò B., De Gori M., Familiari F., Pugliese T., Gasparini G.
    doi: 10.11138/ccmbm/2017.14.1.083
  14. A case report: hypercalcemia due to vitamin supplementation in a patient with neurofibromatosis
    Crone M., Fogarty K.
    doi: 10.11138/ccmbm/2017.14.1.087
  15. Is this a seizure?
    Franceschet G., Mazzucato M., Censi S., Simmini S., Boscaro M., Camozzi V.
    doi: 10.11138/ccmbm/2017.14.1.089
  16. Histological and micro Computed Tomography analysis of a femoral stress fracture associated with prolonged bisphosphonate use
    Somford M.P., van Ruijven L.J., Kloen P., Bakker A.D.
    doi: 10.11138/ccmbm/2017.14.1.092
  17. Primary hyperparathyroidism associated to thrombocytopenia: an issue to consider?
    De Keukeleire S., Muylle K., Tsoumalis G., Vermeulen S., Vogelaers D.
    doi: 10.11138/ccmbm/2017.14.1.097
  18. Acute severe diarrhoea and hyponatremia after zoledronic acid infusion: an acute phase reaction
    Shafi Kuchay M., Farooqui K.J., Mithal A.
    doi: 10.11138/ccmbm/2017.14.1.101
  19. LoCa LoPa myelopathy: is prevention better than cure?
    Pandita K.K., Razdan S., Pandita S.
    doi: 10.11138/ccmbm/2017.14.1.105
Last Viewed articles: la lista degli ultimi x visitati.
  1. Evaluation of bone microstructure in CRPS-affected upper limbs by HR-pQCT
    Mussawy H., Schmidt T., Rolvien T., Rüther W., Amling M.
    doi: 10.11138/ccmbm/2017.14.1.054
credits