Cic edizioni internazionali
Clinical Cases in mineral and bone metabolism

The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis

Original Article, 135 - 140
doi: 10.11138/ccmbm/2016.13.2.135
Tag this article
Abstract
Full text PDF
Objectives. To evaluate whether lumbar vertebral body density CT attenuation values measured in Hounsfield Units (HUs) on routine Computed Tomography (CT) examinations can be reliably measured with limited variability, and to evaluate for a correlation between HUs and bone mineral density as measured by dual energy X-ray absorptiometry (DXA) scan.
Methods. Retrospective review of a total of 249 routine MDCT examinations, performed to measure HUs at the first non-rib bearing lumbar vertebral body on axial images, cross-referenced to the lateral scout image.
Results. The overall ICC and RC for intra-reader variability on CT HU were 0.987 (95% CI 0.973 - 0.999) and 15.664 (95% CI 11.66-16.97). The overall ICC and RDC for interreader variability on CT HU were 0.952 (95% CI 0.892 - 0.999) and 30.20 (95% CI 23.73 - 34.48). The ICC and RC for interscanner variability were 0.98 (95% CI 0.95 - 0.99) and 16.67 (95% CI 13.13 - 22.85). The correlation between the L1 HUs and L1 BMD, L1 t-score, and overall t-score was 0.437, 0.392, and 0.400, respectively.
Conclusions. CT attenuation values of the first lumbar vertebra can be measured on routine abdomen CTs with limited variability despite multiple readers and scanners. Correlation between HU and BMD as measured by DXA scan was only weakly positive, and by this method measuring the density of a lumbar vertebral body from a routine MDCT scan does not provide the sensitivity or specificity necessary for a screening test. However above a certain measured value (180 HU), patients have a low chance of osteoporosis and therefore may not need additional screening, potentially limiting radiation exposure and cost.

Vol. XIII (No. 2) 2016 May-August

  1. From the Editor-in-Chief
    Brandi M.L.
  2. Calcio, vitamina D e fratture: domande e risposte
    Brandi M.L.
    doi: 10.11138/ccmbm/2016.13.2.081
  3. Implications of analgesics use in osteoporotic-related pain treatment: focus on opioids
    Vellucci R., Mattia C., Celidonio L., Mediati R.D.
    doi: 10.11138/ccmbm/2016.13.2.089
  4. The role of drugs in bone pain
    Marras F., Tranquilli Leali P.
    doi: 10.11138/ccmbm/2016.13.2.093
  5. Bone pain mechanism in osteoporosis: a narrative review
    Mattia C., Coluzzi F., Celidonio L., Vellucci R.
    doi: 10.11138/ccmbm/2016.13.2.097
  6. Bone healing in 2016
    Buza III J.A., Einhorn T.
    doi: 10.11138/ccmbm/2016.13.2.101
  7. Abaloparatide
    Gonnelli S., Caffarelli C.
    doi: 10.11138/ccmbm/2016.13.2.106
  8. Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern
    Beltrami G., Ristori G., Scoccianti G., Tamburini A., Capanna R.
    doi: 10.11138/ccmbm/2016.13.2.110
  9. Underdiagnosis of osteoporotic vertebral fractures in patients with fragility fractures: retrospective analysis of over 300 patients
    Bottai V., Giannotti S., Raffaetà G., Mazzantini M., Casella F., De Paola G., Menconi A., Falossi F., Guido G.
    doi: 10.11138/ccmbm/2016.13.2.119
  10. Risk factors of mortality during the first year after low energy osteoporosis fracture: a retrospective case-control study
    Lloret A., Coiffier G., Couchouron T., Perdriger A., Guggenbuhl P.
    doi: 10.11138/ccmbm/2016.13.2.123
  11. Rates and reasons for lack of persistence with anti-osteoporotic drugs: analysis of the Campania region database
    Iolascon G., Gimigliano F., Moretti A., Riccio I., Di Gennaro M., Illario M., Monetti V.M., Orlando V., Menditto E.
    doi: 10.11138/ccmbm/2016.13.2.127
  12. Hyaluronic acid in the management of osteoarthritis: injection therapies innovations
    Santilli V., Paoloni M., Mangone M., Alviti F., Bernetti A.
    doi: 10.11138/ccmbm/2016.13.2.131
  13. The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis
    Burke C.J., Didolkar M.M., Barnhart H.X., Vinson E.N.
    doi: 10.11138/ccmbm/2016.13.2.135
  14. Evaluation of the bone mineral density of the subjects with avascular necrosis of hip joint
    Taghi Karimi M., Mousavi Nodoshan S.M.
    doi: 10.11138/ccmbm/2016.13.2.141
  15. Densitometric evaluation of bone-prosthetic counterface in hip and knee arthroplasty with modern implants
    Cozzi Lepri A., Giorgini M., Signorini C., Carulli C., Civinini R., Brandi M.L., Innocenti M.
    doi: 10.11138/ccmbm/2016.13.2.144
  16. Low-energy trauma-induced intercondylar femoral fracture
    Aeby M., Wyss T., Mentrup B., Kunstmann E., Jakob F., Aeberli D.
    doi: 10.11138/ccmbm/2016.13.2.151
  17. Early onset acute tubular necrosis following single infusion of zoledronate
    Yachoui R.
    doi: 10.11138/ccmbm/2016.13.2.154
  18. Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis
    Torkamani N., Phal P., Savarirayan R., Simm P., Varigos G., Wark J.
    doi: 10.11138/ccmbm/2016.13.2.157
Last Viewed articles: la lista degli ultimi x visitati.
  1. The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis
    Burke C.J., Didolkar M.M., Barnhart H.X., Vinson E.N.
    doi: 10.11138/ccmbm/2016.13.2.135
credits