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Clinical Cases in mineral and bone metabolism

Bone healing in 2016

Mini-review, 101 - 105
doi: 10.11138/ccmbm/2016.13.2.101
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Abstract
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Delayed fracture healing and nonunion occurs in up to 5- 10% of all fractures, and can present a challenging clinical scenario for the treating physician. Methods for the enhancement of skeletal repair may benefit patients that are at risk of, or have experienced, delayed healing or nonunion. These methods can be categorized into either physical stimulation therapies or biological therapies.
Physical stimulation therapies include electrical stimulation, low-intensity pulsed ultrasonography, or extracorporeal shock wave therapy. Biological therapies can be further classified into local or systemic therapy based on the method of delivery. Local methods include autologous bone marrow, autologous bone graft, fibroblast growth factor-2, platelet-rich plasma, platelet-derived growth factor, and bone morphogenetic proteins. Systemic therapies include parathyroid hormone and bisphosphonates. This article reviews the current applications and supporting evidence for the use of these therapies in the enhancement of fracture healing.

Vol. XIII (No. 2) 2016 May-August

  1. From the Editor-in-Chief
    Brandi M.L.
  2. Calcio, vitamina D e fratture: domande e risposte
    Brandi M.L.
    doi: 10.11138/ccmbm/2016.13.2.081
  3. Implications of analgesics use in osteoporotic-related pain treatment: focus on opioids
    Vellucci R., Mattia C., Celidonio L., Mediati R.D.
    doi: 10.11138/ccmbm/2016.13.2.089
  4. The role of drugs in bone pain
    Marras F., Tranquilli Leali P.
    doi: 10.11138/ccmbm/2016.13.2.093
  5. Bone pain mechanism in osteoporosis: a narrative review
    Mattia C., Coluzzi F., Celidonio L., Vellucci R.
    doi: 10.11138/ccmbm/2016.13.2.097
  6. Bone healing in 2016
    Buza III J.A., Einhorn T.
    doi: 10.11138/ccmbm/2016.13.2.101
  7. Abaloparatide
    Gonnelli S., Caffarelli C.
    doi: 10.11138/ccmbm/2016.13.2.106
  8. Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern
    Beltrami G., Ristori G., Scoccianti G., Tamburini A., Capanna R.
    doi: 10.11138/ccmbm/2016.13.2.110
  9. Underdiagnosis of osteoporotic vertebral fractures in patients with fragility fractures: retrospective analysis of over 300 patients
    Bottai V., Giannotti S., Raffaetà G., Mazzantini M., Casella F., De Paola G., Menconi A., Falossi F., Guido G.
    doi: 10.11138/ccmbm/2016.13.2.119
  10. Risk factors of mortality during the first year after low energy osteoporosis fracture: a retrospective case-control study
    Lloret A., Coiffier G., Couchouron T., Perdriger A., Guggenbuhl P.
    doi: 10.11138/ccmbm/2016.13.2.123
  11. Rates and reasons for lack of persistence with anti-osteoporotic drugs: analysis of the Campania region database
    Iolascon G., Gimigliano F., Moretti A., Riccio I., Di Gennaro M., Illario M., Monetti V.M., Orlando V., Menditto E.
    doi: 10.11138/ccmbm/2016.13.2.127
  12. Hyaluronic acid in the management of osteoarthritis: injection therapies innovations
    Santilli V., Paoloni M., Mangone M., Alviti F., Bernetti A.
    doi: 10.11138/ccmbm/2016.13.2.131
  13. The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis
    Burke C.J., Didolkar M.M., Barnhart H.X., Vinson E.N.
    doi: 10.11138/ccmbm/2016.13.2.135
  14. Evaluation of the bone mineral density of the subjects with avascular necrosis of hip joint
    Taghi Karimi M., Mousavi Nodoshan S.M.
    doi: 10.11138/ccmbm/2016.13.2.141
  15. Densitometric evaluation of bone-prosthetic counterface in hip and knee arthroplasty with modern implants
    Cozzi Lepri A., Giorgini M., Signorini C., Carulli C., Civinini R., Brandi M.L., Innocenti M.
    doi: 10.11138/ccmbm/2016.13.2.144
  16. Low-energy trauma-induced intercondylar femoral fracture
    Aeby M., Wyss T., Mentrup B., Kunstmann E., Jakob F., Aeberli D.
    doi: 10.11138/ccmbm/2016.13.2.151
  17. Early onset acute tubular necrosis following single infusion of zoledronate
    Yachoui R.
    doi: 10.11138/ccmbm/2016.13.2.154
  18. Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis
    Torkamani N., Phal P., Savarirayan R., Simm P., Varigos G., Wark J.
    doi: 10.11138/ccmbm/2016.13.2.157
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