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Clinical Cases in mineral and bone metabolism

Bone pain mechanism in osteoporosis: a narrative review

Mini-review, 97 - 100
doi: 10.11138/ccmbm/2016.13.2.097
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Abstract
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Bone pain in elderly people dramatically affects their quality of life, with osteoporosis being the leading cause of skeletal related events. Peripheral and central mechanisms are involved in the pathogenesis of the nervous system sensitization. Osteoporosis in the elderly has been associated with increased density of bone sensory nerve fibers and their pathological modifications, together with an over-expression of nociceptors sensitized by the lowering pH due to the osteoclastic activity. The activation of Nmethyl-D-aspartate (NMDA) receptors and the microglia, as a response to a range of pathological conditions, represent the leading cause of central sensitization. Unfortunately, osteoporosis is named the “silent thief” because it manifests with painful manifestation only when a fracture occurs. In the management of patients suffering from bone pain, both the nociceptive and the neuropathic component of chronic pain should be considered in the selection of the analgesic treatment.

Vol. XIII (No. 2) 2016 May-August

  1. From the Editor-in-Chief
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  2. Calcio, vitamina D e fratture: domande e risposte
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  3. Implications of analgesics use in osteoporotic-related pain treatment: focus on opioids
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  4. The role of drugs in bone pain
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  5. Bone pain mechanism in osteoporosis: a narrative review
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    doi: 10.11138/ccmbm/2016.13.2.097
  6. Bone healing in 2016
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  7. Abaloparatide
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  8. Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern
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  10. Risk factors of mortality during the first year after low energy osteoporosis fracture: a retrospective case-control study
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