Cic edizioni internazionali
Clinical Cases in mineral and bone metabolism

Current medical treatment strategies concerning fracture healing

Mini-reviews, 116 - 120
doi: 10.11138/ccmbm/2013.10.2.116
Tag this article
Abstract
Enhanced HTML Full text PDF
The morbidity and socioeconomic costs associated with bone healing are considerable. A number of fractures are complicated by impaired healing. This is prevalent in certain risk groups such as elderly, osteoporotics, postmenopausal women, and in people with malnutrition.
The biologic process of fracture healing is complex and impacted by multiple factors. Some of them, such as the nutritional and health conditions, are patient-dependent, while others depend on the trauma experienced and stability of the fracture. Fracture healing disorders negatively affect the patient’s quality of life and result in high healthcare costs, as a second surgery is required to stabilize the fracture and stimulate bone biology. Future biotechnologies that accelerate fracture healing may be useful tools, which might also prevent the onset of these disorders.
We list the characteristics of the drugs used for osteoporosis, but we point out in particular the use of strontium ranelate and teriparatide in our clinical practice in elderly patients, especially females, who reported fractures with risk of nonunion.
This medical treatment could impaired fracture healing however, most of the evidence is obtained in animal studies and very few studies have been done in humans.
Thus one could hypothesize the possibility of a medical treatment both as a preventive and as support to the synthesis.
However, no clinical studies are available so far, and such studies are warranted before any conclusions can be drawn.
A positive effect of osteoporosis treatments on bone healing is an interesting possibility and merits further clinical research.

Vol. XIII (No. 2) 2016 May-August

  1. From the Editor-in-Chief
    Brandi M.L.
  2. Calcio, vitamina D e fratture: domande e risposte
    Brandi M.L.
    doi: 10.11138/ccmbm/2016.13.2.081
  3. Implications of analgesics use in osteoporotic-related pain treatment: focus on opioids
    Vellucci R., Mattia C., Celidonio L., Mediati R.D.
    doi: 10.11138/ccmbm/2016.13.2.089
  4. The role of drugs in bone pain
    Marras F., Tranquilli Leali P.
    doi: 10.11138/ccmbm/2016.13.2.093
  5. Bone pain mechanism in osteoporosis: a narrative review
    Mattia C., Coluzzi F., Celidonio L., Vellucci R.
    doi: 10.11138/ccmbm/2016.13.2.097
  6. Bone healing in 2016
    Buza III J.A., Einhorn T.
    doi: 10.11138/ccmbm/2016.13.2.101
  7. Abaloparatide
    Gonnelli S., Caffarelli C.
    doi: 10.11138/ccmbm/2016.13.2.106
  8. Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern
    Beltrami G., Ristori G., Scoccianti G., Tamburini A., Capanna R.
    doi: 10.11138/ccmbm/2016.13.2.110
  9. Underdiagnosis of osteoporotic vertebral fractures in patients with fragility fractures: retrospective analysis of over 300 patients
    Bottai V., Giannotti S., Raffaetà G., Mazzantini M., Casella F., De Paola G., Menconi A., Falossi F., Guido G.
    doi: 10.11138/ccmbm/2016.13.2.119
  10. Risk factors of mortality during the first year after low energy osteoporosis fracture: a retrospective case-control study
    Lloret A., Coiffier G., Couchouron T., Perdriger A., Guggenbuhl P.
    doi: 10.11138/ccmbm/2016.13.2.123
  11. Rates and reasons for lack of persistence with anti-osteoporotic drugs: analysis of the Campania region database
    Iolascon G., Gimigliano F., Moretti A., Riccio I., Di Gennaro M., Illario M., Monetti V.M., Orlando V., Menditto E.
    doi: 10.11138/ccmbm/2016.13.2.127
  12. Hyaluronic acid in the management of osteoarthritis: injection therapies innovations
    Santilli V., Paoloni M., Mangone M., Alviti F., Bernetti A.
    doi: 10.11138/ccmbm/2016.13.2.131
  13. The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis
    Burke C.J., Didolkar M.M., Barnhart H.X., Vinson E.N.
    doi: 10.11138/ccmbm/2016.13.2.135
  14. Evaluation of the bone mineral density of the subjects with avascular necrosis of hip joint
    Taghi Karimi M., Mousavi Nodoshan S.M.
    doi: 10.11138/ccmbm/2016.13.2.141
  15. Densitometric evaluation of bone-prosthetic counterface in hip and knee arthroplasty with modern implants
    Cozzi Lepri A., Giorgini M., Signorini C., Carulli C., Civinini R., Brandi M.L., Innocenti M.
    doi: 10.11138/ccmbm/2016.13.2.144
  16. Low-energy trauma-induced intercondylar femoral fracture
    Aeby M., Wyss T., Mentrup B., Kunstmann E., Jakob F., Aeberli D.
    doi: 10.11138/ccmbm/2016.13.2.151
  17. Early onset acute tubular necrosis following single infusion of zoledronate
    Yachoui R.
    doi: 10.11138/ccmbm/2016.13.2.154
  18. Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis
    Torkamani N., Phal P., Savarirayan R., Simm P., Varigos G., Wark J.
    doi: 10.11138/ccmbm/2016.13.2.157
Last Viewed articles: la lista degli ultimi x visitati.
  1. Current medical treatment strategies concerning fracture healing
    Giannotti S., Bottai V., Dell'osso G., Pini E., De Paola G., Bugelli G., Guido G.
    doi: 10.11138/ccmbm/2013.10.2.116
credits