Giant cell tumor in a case of Paget's disease of bone: an aggressive benign tumor exhibiting a quick response to an innovative therapeutic agent
Case report, 145 - 152Tag this article
Giant cell tumor of bone, also called osteoclastoma, is a rare skeletal complication of Paget’s disease of bone. We here report a patient from Southern Italy who developed a GCT infiltrating the neighboring tissues. We will focus on either a review on this rare bone tumor, including some genetic aspects, or the current established therapies. Since this case has been published in International literature, here we report the updated clinical findings on it. Finally, we will describe the therapeutic outcomes of this unique complication of Paget’s disease of bone as a rapid response to an innovative therapeutic agent.
KEY WORDS: Paget’s disease of bone; giant cell tumors; osteoclastoma; RANKL/RANK/OPG; anti-RANKL antibody.