Cic edizioni internazionali
Clinical Cases in mineral and bone metabolism

Immunohistochemical analysis of new bone formation in a patient with retroperitoneal liposarcoma; a case report

Case report, 178 - 180
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In April 2013, a 73-years-old Japanese man was admitted to our institute for the evaluation of metastatic liposarcoma. Soft tissue adjacent to the bone tissue was investigated immunohistochemically to evaluate the mechanism of new bone formation. Multinucleated giant cells accumulating on the bone tissue surface were strongly positive for tartrate- resistant acid phosphatase (TRAP) and cathepsin K, satisfying the histochemical criteria for identification of osteoclasts. In contrast, mononuclear cells on the bone tissue surface demonstrated immunopositivity for alkaline phosphatase (ALP) and were associated with osteocalcin staining of the bone surface and interior, indicating that these cells were probably osteoblasts.

Vol. XVI (No. 2) 2019 May - August

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