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Clinical Cases in mineral and bone metabolism

Severe and generalized subcutaneous calcinosis in CREST Syndrome

Case report, 168
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Abstract
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A 60-year-old female with severe pain in extremities had skin thickening in hands to elbows and feet to knees, loss of skin folds, microstomia and digital pitting scars. A CREST (Calcinosis, Raynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly, Telangiectasias) syndrome was diagnosed. The generalized calcinosis made difficult a surgical treatment. Diltiazem alone or in combination with other drugs could be a useful therapy in patients with pronounced calcifications.

Vol. XVI (No. 2) 2019 May - August

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