Cic edizioni internazionali
Clinical Cases in mineral and bone metabolism

Lean Body Mass is a determinant of bone mineral measurements in American adolescents

Original Article, 119 - 126
Tag this article
Full text PDF
Background. Studies have demonstrated direct correlations between birthweight and body composition on adultonset osteoporosis. Objective. Determine the impact of birthweight and body composition in American adolescents on total bone mineral content excluding head (tBMC) and total bone mineral density excluding head (tBMD). Design/Methods. Cross-sectional study of individuals 13 to 15 years old who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006. Primary outcome. Total body excluding head BMC (tBMC) and total body excluding head BMD (tBMD). Results. The cohort consisted of 1,295 males and 1051 females with an overall average age of 14 ± 0.8 years. tBMC, tBMD, and lean body mass index (LBMI) were greater in males than in females (tBMC: 1,330 ± 398 g vs. 1,115 ± 247 g, p<0.001; tBMD: 0.741± 0.13 g/cm2 vs. 0.686 ± 0.09 g/cm2, p<0.001; LBMI: 1.63 ± 0.27 g/cm2 vs. 1.47 ± 0.22 g/cm2, p<0.001). Fat mass index (FMI) was lower in males than in females (0.603 ± 0.36 g/cm2 vs. 0.812 ± 0.37 g/cm2, p<0.001). Significant correlations were seen between LBMI and tBMC (males: p<0.001, r2=0.51; females: p<0.001, r2=0.40) and tBMD (males: p<0.001, r2=0.42; females: p<0.001, r2=0.32). Weaker, statistically positive correlations were seen between birthweight and tBMC (males: p<0.002, r2=0.007; females: p<0.001, r2=0.028) and with tBMD (males: p<0.073, r2=0.003; females: p<0.01, r2=0.011). Birthweight, gender, age, ethnicity, phosphorus levels, FMI, and LBMI were the main determinants of tBMC (r2=0.61). This multivariate model was stronger than LBMI alone at predicting the variance of bone mineral measurements in adolescents. Conclusions. In our study, birthweight had a slight correlation with bone mineral measurements, but LBMI was a far greater determinant of tBMC and tBMD in adolescents.

Vol. XVI (No. 2) 2019 May - August

  1. From the Editor-in-Chief
    Brandi M.L.
  2. Bone quality, vertebral fragility fractures and intervertebral disc calcifications in patients with transfusion-dependent β-thalassemia
    de Sire A., Invernizzi M., Moretti A., Curci C., Toro G., Casale M., Perrotta S., Gimigliano F., Iolascon G.
  3. FRA-HS score: two-year experience
    Michieli R., Zerbinati C.
  4. Lean Body Mass is a determinant of bone mineral measurements in American adolescents
    Das H., Peñon C., Bedgood M., Sakka E., Ortiz J., Bansal N., Shah S., Moreira A.
  5. Pediatric non-rhabdomyosarcoma soft tissue sarcoma: heterogeneous group of rare tumors treated with a multidisciplinary approach
    Beltrami G., Ristori G., Tamburini A., Lazzarini F., Scocciantini G., Muratori F., Franchi A., Palomba A., Roselli G., Greto D., Mangoni M., Capanna R., Campanacci D.A.
  6. Pharmacological therapy of knee osteoarthritis - an update
    Minisola G.
  7. The use of new genetic technologies in patient approach: a mini-review of the literature
    De Bernardo M.L., Zuffardi O., Iolascon A.
  8. Sarcopenic dysphagia: a narrative review
    Invernizzi M., Baricich A., Riso S., Lippi L., Cisari C., de Sire A.
  9. Atypical femoral fracture. A diagnostic challenge in glucocorticoid-induced osteoporosis
    Azuaga-Piñango A.B., Muxí A., González E., Peris P.
  10. Atypical presentation of Paget’s Disease of bone manifesting in the right humerus: a case report
    Luibil N.L., Connelly J.R.
  11. Synchronous presence of two ossified intramuscular hemangiomas of the leg investigated by Tc-99m hydroxymethylene diphosphonate three-phase bone scan and SPECT-CT: case report and literature review
    Calandri E., Pultrone M., Parafioriti A., Bastoni S., Gallina S., Aretano I., Conversano L., Tua A., Perfetti E., Sella M., Liberatore M.
  12. Osteochondroma: is it always easy to face with? A case series of difficult removals
    Cosseddu F., Shytaj S., Sacchetti F., Ceccoli M., Grossi S., Andreani L., Capanna R.
  13. Severe and generalized subcutaneous calcinosis in CREST Syndrome
    Brance M.L., Gilli V.
  14. Bicipitoradial bursitis a case report
    Mattugini V., Citarelli C., Agostini G., Lazzerini I., Sacchetti F., Capanna R.
  15. The bone growth potential of vascularized free fibular autografts: callotasis treatment of a limb-length discrepancy, a case report
    Agostini G., Sacchetti F., Citarelli C., Cesari M., Ceri L., Capanna R., Giannotti S.
  16. Immunohistochemical analysis of new bone formation in a patient with retroperitoneal liposarcoma; a case report
    Hoshino J., Hasegawa T., Hiramatsu R., Mizuno H., Sekine A., Kawada M., Sumida K., Hayami N., Yamanouchi M., Hasegawa E., Suwabe T., Sawa N., Takaichi K., Amizuka N., Hashimoto M., Ubara Y.
  17. Malignant pigmented villonodular synovitis: a brief literature review and a case report
    Cosseddu F., Shytaj S., Sacchetti F., D'Arienzo A., Andreani L., Capanna R.
Last Viewed articles: la lista degli ultimi x visitati.
  1. Lean Body Mass is a determinant of bone mineral measurements in American adolescents
    Das H., Peñon C., Bedgood M., Sakka E., Ortiz J., Bansal N., Shah S., Moreira A.