Lung cancer with hypertrophic pulmonary osteoarthropathy mimicking acromegaly
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Lung cancer is known to be common in old ages. Hy- pertrophic pulmonary osteoarthropathy (HPOA) also appeared to be rare with pulmonary malignancies. We report a case of middle-aged man with lung cancer with HPOA mimicking acromegaly. Simple X-rays for hand, foot, leg and thigh showed periosteal proliferation of new bone. Whole body bone scan showed increased and diffuse uptake along cortical margins of diaph- ysis and metaphysic of both femurs and both tibias. Serum IGF-1 level was normal. The peripheral needle approached biopsy was performed for 4.5 cm sized tu- mor in right upper lobe of lung. The biopsy specimen showed adenocarcinoma. HPOA may exist uncommonly in a secondary form associated with pulmonary malig- nancies and is a rare paraneoplastic manifestation.
KEY WORDS: hypertrophic osteoarthropathy; adenocarcinoma; acromegaly; paraneoplastic.