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Clinical Cases in mineral and bone metabolism

A case of adult chronic recurrent multifocal osteomyelitis successfully treated with neridronate

Case report, 75 - 79
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Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an inflammatory bone disease characterized by sterile osteomyelitis. CRMO is characterized by the presence of multiple and recurrent foci of sterile osteomyelitis, usually involving the metaphysis of long bones, pelvis, clavicle and jaw and mainly affects children and ado- lescents even though adult forms have been described. The diagnosis requires the presence of consistent clin- ical imaging and laboratory features. Not rarely, biopsy is needed. CRMO treatment is not standardised, usually first-line approach consist of non- steroidal anti-inflam- matory drugs. Second-line treatment implies the use of corticosteroids, bisphosphonates, immunosuppres- sant and, in selected cases, anti Tumor Necrosis Factor α (TNF-α). We report a case of CRMO in a 24-year-old, semi-professional basketball player.
After a partial re- sponse to anti-inflammatory treatment, he was admin- istered with i.v. neridronate with a good response and achievement of clinical remission.

Vol. XVI (No. 1) 2019 January - April

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