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Clinical Cases in mineral and bone metabolism

Incidental finding of osteopetrosis complicated with osteomyelitis

Case report, 371 - 374
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Abstract
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Osteopetrosis is a sporadic hereditary bone disorder showing variable clinical features and is characterized by an increase in bone density and reduction of marrow spaces that result from a defect in the function of osteoclasts and, consequently, a decrease in bone turnover. This disease is usually divided into three categories: severe infantile malignant autosomal recessive, intermediate mild autosomal recessive, and benign autosomal dominant. The prognosis of the first two types of osteopetrosis is poor and it is characterized by an early onset, mostly within the first decade of life, and early death. The benign-type is characterized by a later onset usually in adulthood and a longer life span. Ten percent of osteopetrosis cases develops osteomyelitis and is commonly caused by tooth extraction or pulpal necrosis.
The reported case is incidental finding of intermediate recessive osteopetrosis complicated by chronic osteomyelitis.

Vol. XV (No. 3) 2018 September - December

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