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Clinical Cases in mineral and bone metabolism

Acute deafness as the first symptom of paraneoplastic syndrome: experience of two cases

Case report, 111 - 114
doi: 10.11138/ccmbm/2018.15.1.111
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Abstract
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PNS (Paraneoplastic syndrome) is the primary malignant tumor in patients with distant organs dysfunction. PNS is associated with the products of tumors, abnormal immune responses or other unknown reasons which can cause endocrine, nerves, digestive, hematopoietic, joint, kidneys, and skin lesions, resulting in various clinical manifestations. The clinical data of 2 cases of patients with PNS and acute deafness as the first symptom was analyzed retrospectively. The data including history, physical examination, laboratory tests, diagnosis, and treatment were collected and analyzed. Both patients are women. Malignancies were screened and detected by cell pathology, while the pathological diagnoses were obtained through biopsy or lumbar puncture. Both of the patients received early immunosuppressive treatment in terms of corticosteroids, only slight relief of neurological symptoms was seen in them. During the follow-up, 2 patients were transferred to relative departments for the treatment of primary disease. In general, the management
of PNS is based on the treatment of associated cancer. Quick identification is really important to avoid delay in diagnosis and treatment.

Vol. XV (No. 2) 2018 May - August

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