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Clinical Cases in mineral and bone metabolism

The use of null-hypothesis significance testing: issues and solutions

Mini-Review, 9 - 15
doi: 10.11138/ccmbm/2018.15.1.009
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Abstract
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The pervasive use of null hypothesis significance testing (NHST) within biomedical research has been controversial for almost half a century, and recently this issue has been brought up again due to the recent scientific debate about the “replication problem.” From a historical point of view, NHST is a hybrid approach that incongruently combines the “p-value approach” (PVA) proposed by Ronald Fisher and the “fixed-alpha approach” (FAA) proposed by Jerzy Neyman and Egon Pearson.
Consequently, the NHST procedure is subject to considerable limitations and lends itself to misunderstanding. In this paper, the most important of these problems are reviewed and the main concepts of NHST are correctly interpreted. Other practices beyond NHST are also outlined.
In particular, Bayesian inference is briefly presented as the main alternative to NHST.

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    doi: 10.11138/ccmbm/2018.15.1.009
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